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Soft Bioelectronics for In Vivo Neural Probes

Existing high-resolution neural recording devices cannot achieve simultaneous scalability on both spatial and temporal levels due to a trade-off between sensor density and mechanical flexibility. A team led by Liu, Bertoldi, Kozinsky, and Suo has introduced a three-dimensional (3D) stacking implantable electronic platform, based on perfluorinated dielectric elastomers and tissue-level soft multilayer electrodes, that enables spatiotemporally scalable single-cell neural electrophysiology. The 3D integrated multilayer soft electrode array retains tissue-level flexibility, reduces chronic immune responses when implanted in neural tissues, and reliably tracks electrical activity in a mouse brain over months.