Using Reversible Addition Fragmentation Chain Transfer (RAFT), ABA block copolymers can be synthesized, where the A blocks exhibit a lower critical solution temperature (LCST) and the B blocks are permanently hydrophilic. The polymeric solution will transition from a liquid to a gel as the temperature is increased to physiological conditions, 37Â°C. These reversible polymeric gels may serve as three dimensional scaffolds for cell growth. Current research shows that cells grown in a three dimensional environment are more representative of in vivo growth.
S.Kirkland, T. Convertine, and C.L. McCormick