Working collaboratively, research groups at the Chicago MRSEC have developed new label-free analytical systems that utilize ultra-small sample sizes of cellular lysate, yet allow these single samples to be assayed for multiple kinase activities. The systems involve the integration of solid-phase biochip peptide arrays, mass spectrometric detection, and microfluidic networks.  We expect this strategy to aid drug discovery, diagnostics, and other basic research which rely substantially on enzyme assays.
 Combining Microfluidic Networks and Peptide Arrays for Multi-Enzyme Assays, J. Su, M. R. Bringer, R. Ismagilov, and M. Mrksich, J. Am. Chem. Soc., 127, 7289-7281, 2005.