The Center for Advanced Materials & Manufacturing (CAMM), a Materials Research Science and Engineering Center (MRSEC) at the University of Tennessee (UT), Knoxville, focuses on the exploration, discovery, and design of new materials with properties of critical societal importance for energy, transport, and security advancements. CAMM brings together experts from diverse fields to make groundbreaking discoveries in two areas: (1) materials for future quantum technologies, and (2) advanced materials for extreme conditions. To tackle these challenges, CAMM utilizes the latest advances in artificial intelligence (AI) together with neutron scattering, materials synthesis, and modeling. Interdisciplinary research group (IRG) 1 is dedicated to accelerating the understanding, design, and control of quantum materials and systems through the use of AI with advances expected in the design of materials for energy harvesting, low-power electronics, quantum computing, and novel sensing applications. CAMM?s second IRG focuses on developing materials that can withstand extreme temperatures and pressure needed for nuclear fusion and hypersonic defense systems. These applications require high-performance structural materials not available today, and CAMM researchers are increasing the understanding of the structure, properties, and processing relationship to uncover new and enhanced materials with superior properties capable of performing in such harsh operating environments. At the core of CAMM is a culture of research, innovation, and learning. The center provides opportunities for undergraduate and graduate students, as well as postdoctoral trainees, to prepare for careers as researchers, entrepreneurs, and innovators in academia, industry, and national laboratories. These students gain the necessary skills and knowledge to engage in AI-enabled discovery and innovation. CAMM is committed to promoting diversity, equity, and inclusion and works closely with minority serving institutions in the Southeast US to address the lack of diversity in STEM fields. CAMM offers mechanisms for collaborative research and technology translation as well as access to unique research resources and shared facilities in AI and extreme conditions making it an important center for advancing scientific knowledge and innovation in the country.