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View World Anti-Doping Agency classifications, Prevention of Thromboembolism in Atrial Fibrillation, Prosthetic Heart Valves - Thrombosis Prophylaxis, Prosthetic Heart Valves - Mechanical Valves - Thrombosis Prophylaxis, Revascularization Procedures - Prophylaxis. These relax smooth muscle within the blood vessels, widening them and making it easier for blood and oxygen to reach the heart Calcium antagonists (eg, diltiazem, nifedipine, nimodipine, verapamil). Portions of this document last updated: Feb. 01, 2023. Along with its needed effects, a medicine may cause some unwanted effects. National Library of Medicine The body tends to develop a tolerance (decreased sensitivity) to ISMN when it is used continuously over 24 hours. Saper RB. Learn to reduce stress through mindful living. Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. Isosorbide mononitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). Valerian: A safe and effective herbal sleep aid? Copyright, 2023. What is the difference between the immediate-release (IR) and extended-release (ER) versions of isosorbide mononitrate (Monoket)? Cleophas TJ, Niemeyer MG, van Der Wall EE. Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. My EKG showed Assess your symptoms online with our free symptom checker. Isosorbide-5-mononitrate ISMN usually begins acting within 30 minutes and its effects last six to eight hours. Take care, thanks. Some conditions may become worse when the drug is suddenly stopped. May also be prescribed off label for Esophageal Spasm. 2017; doi:10.1016/j.jacc.2016.11.078. Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. The Swedish Multicentre Group. Higher dosages are associated with stomach irritation and If you become pregnant while taking isosorbide, call your doctor. An official website of the United States government. Before Many common herbal supplements interact with common heart medicines. It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Accessed Sept. 7, 2022. Then, there was a two-week placebo washout, after which the alternative treatment was given. ** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. This activity describes the indications, action, and contraindications for isosorbide as a valuable agent in treating angina pectoris due to coronary artery disease, heart failure with reduced . This is a condition where the heart does not beat as efficiently as it should. you should know that you may experience headaches every day during your treatment with isosorbide. See also: nitroglycerin side effects in more detail. St. John's wort. Many herbal supplements can interact with prescription drugs. Browse all drugs on eHealthMe. https://naturalmedicines.therapeuticresearch.com. Also, it is not intended to be taken just before physical activities (such as exercise or sexual intercourse) to prevent chest pain. Imdur (isosorbide mononitrate) Extended Release and Isordil (isosorbide dinitrate) are vasodilators indicated for the prevention of angina pectoris due to coronary artery disease.. Side effects of Imdur and Isordil that are similar include headache and dizziness.. Side effects of Isordil that are different from Imdur include weakness and skin changes such as redness, tingling, or warmth. It is unknown if this medication passes into breast milk. For haemoglobin formation vit. Each day, take the first dose when you wake up, then take the second dose 7 hours later. Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Try to keep your regular appointments with your doctor. Watch for any symptoms that you may be having a drug interaction, such as: Mayo Clinic does not endorse companies or products. May also be prescribed off label for Esophageal Spasm. Store in a cool, dry place, away from direct heat and light. FOIA Keep all medicines out of the reach and sight of children. Accessed Sept. 7, 2022. Ask your doctor before using aspirin together with alcohol. Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. Mehta D. Herbal & dietary supplements. When used regularly on a long-term basis, this helps prevent angina attacks from occurring. All rights reserved. Take extra precautions to avoid falling during your treatment with isosorbide. McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. (3) The overall number of headache attacks in the first period of active treatment was significantly higher than in the second period irrespective of the dosages given. Isosorbide mononitrate dose 10 mg twice daily to 120 mg daily in divided doses. Do not take more or less of it or take it more often than prescribed by your doctor. Bauer B (expert opinion). This medicine is available only with your doctor's prescription. Be sure to follow your provider's instructions about when to take isosorbide mononitrate (Monoket). Once- versus twice-daily administration of controlled-release isosorbide-5-mononitrate 60 mg in the treatment of stable angina pectoris. It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen. Accessed Sept. 7, 2022. To view a report comparing 3 (or more) medications, please sign in or create an account. prevention of anginal chest pain associated with coronary artery disease, prevent bleeding varicose vein in the esophagus. See the full pregnancy warnings document. You can take your doses either before or after meals. Lifestyle changes such as dietary changes, exercise, and not smoking may help this drug work better. Background: Fish Oil (omega-3 polyunsaturated fatty acids), Email this report to a friend, doctor, or patient, isosorbide mononitrate consumer information. Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to this medication. About one-half of adults in the United States say they have used one or more supplements in the past 30 days. Isosorbide mononitrate tablets and capsules are not suitable to take to treat the pain of an angina attack. This list covers only some interactions. If we combine this information with your protected Alcohol, including beer, wine, and spirits, does raise your blood pressure if its consumed in excess. Symptoms of overdose may include: slow heartbeat, vision changes, severe nausea/vomiting, sweating, cold/clammy skin, bluish fingers/toes/lips. 19 are major, 174 are moderate, and 2 are minor. Higher than recommend dosage of sublingual isosorbide dinitrate for treating angina pectoris: a case report and review of the literature. DUMQOL (DUtch Mononitrate Quality of Life) Study Group. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Alternative cancer treatments: 11 options to consider. Alcohol can make the side effects from isosorbide worse. 2005 - 2023 WebMD LLC. Careers. Isosorbide mononitrate belongs to the group of medicines called nitrates. This risk may be even higher for certain groups. Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets; Merus Labs Luxco S.a.R.L, The electronic Medicines Compendium. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). It also may keep some medicines from working as well as they should, such as: If your health care provider tells you it's OK to use an herbal supplement along with medicine, be careful. Take this medication by mouth as directed by your doctor, usually twice a day. Liperoti R, et al. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Isosorbide mononitrate works in two ways. 88 ratings on Drugs.com. Nitroglycerin works very quickly to widen your blood vessels and help your heart pump blood during a heart attack. You can start a phase IV clinical trial to monitor Isosorbide mononitrate safety and effectiveness. Vascular dilatation can precipitate venous pooling with decreased return to the heart, hypotension and reflex tachycardia. Minimally clinically significant. Isosorbide mononitrate has an average rating of 7 disease interactions. Classes: Nitrates, Angina Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet 10mg 20mg. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. You can consult me online for homeopathic treatment. Let your provider know if they are excessive. In: Current Medical Diagnosis & Treatment 2022. Do not take a double dose to make up for a missed one. If you buy any medicines, please check with a pharmacist that they are suitable for you to take with isosorbide mononitrate. Danshen. I took this for 4 days, and my headaches were unbearable. Herbal supplements are natural, so they must be safe, right? Natural remedies for depression: Are they effective? Isosorbide mononitrate (Monoket) is available as both a immediate-release (IR, short-acting) and extended-release (ER, long-acting) tablet. Isosorbide mononitrate is used to prevent chest pain in patients with a certain heart condition (coronary artery disease).This medication belongs to a class of drugs known as nitrates. This document does not contain all possible drug interactions. If you forget to take a dose, take it as soon as you remember. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Isosorbide mononitrate Aspirin Prescription only Prescribed for Angina Pectoris Prophylaxis, Heart Failure. This content does not have an Arabic version. tell your doctor if you may be dehydrated, if you have recently had a heart attack, or if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles). [2] It is taken by mouth. Keep this medication in the container it came in, tightly closed, and out of reach of children. Breastfeeding:There is data that nitrates are excreted in breast milk and may cause methemoglobinemia in infants. Methods: Use this medication regularly to get the most benefit from it. This content does not have an English version. This is so your doctor can check on your progress. These headaches may be a sign that the medication is working as it should. Accessed Sept. 7, 2022. ask your doctor about the safe use of alcoholic beverages while you are taking isosorbide. Do not stop taking isosorbide without talking to your doctor. A very serious allergic reaction to this drug is rare. The authors assessed the occurrence of angina pectoris and headache by diary cards while taking into account the number of isosorbide dinitrate sublingual puffs and paracetamole tablets required. A total of 195 drugs are known to interact with isosorbide mononitrate: A total of 330 drugs are known to interact with aspirin: A total of 239 drugs are known to interact with nitroglycerin: No known alcohol/food interactions. Instead, the best way to dispose of your medication is through a medicine take-back program. Is it safe to drive while on this medicine? This is called tolerance, and it cannot be fixed by raising the dose of the medication. The narrowing makes it more difficult for blood to flow to your heart muscle. The extended-release tablet usually is taken once daily in the morning. Dated August 2017. [2] If concomitant therapy cannot be avoided, monitor clinical effects of the . This medicine is for you. Your doctor will tell you which is the right dose for you, and this will also be printed on the label of the pack to remind you about what the doctor said to you. Who should not take Isosorbide Mononitrate? Danshen can interact strongly with some heart medicines, such as: Evening primrose may raise your risk of bleeding if you also take a blood thinner, such as: Garlic may raise your risk of bleeding if you also take a blood thinner, such as: Ginkgo biloba may raise your risk of bleeding if you also take a blood thinner, such as: If you take ginseng with warfarin, it may lessen how well warfarin works. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. Prescription and OTC It works by relaxing and widening blood vessels so blood can flow more easily to the heart.This medication will not relieve chest pain once it occurs. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide dinitrate, nitroglycerin); or if you have any other allergies. All rights reserved. What happens if I stop taking isosorbide mononitrate (Monoket)? Longer-acting tablets and capsules are taken once daily in the morning. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. information is beneficial, we may combine your email and website usage information with Nitroglycerin has an average rating of Alternative drugs to the conditions Isosorbide mononitrate treats: Angina High blood pressure Stable angina Chest pain Heart disease Heart attack Angina unstable Heart disease congenital Coronary heart disease Heart failure Pulse Heart rate irregular Coronary artery spasm Angioplasty Overview of herbal medicines and dietary supplements. and transmitted securely. coma (loss of consciousness for a period of time). (1) Starting on a low dosage was associated with a reduced frequency and severity of headache and did not notably influence the beneficial effect on angina pectoris. Prescribed for Angina, Anal Fissure and Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. Stopping isosorbide mononitrate (Monoket) suddenly can cause you to have a worsening of your chest pain. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. However, you should not flush this medication down the toilet. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. I strongly feel that there is coronary ischemia. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Below is the list of medicines, which contains Isosorbide Mononitrate as ingredient. Discuss the risks and benefits with your doctor. We don't support your browser. Other medications may be prescribed by your doctor for these conditions. https://naturalmedicines.therapeuticresearch.com. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). This medicine is a white, round, scored, tablet imprinted with "KU 107" and "20". Are you looking for information on isosorbide dinitrate (Isordil) instead? The tablet usually is taken two or three times daily. AskMayoExpert. To avoid this problem, get up slowly, resting your feet on the floor for a few minutes before standing up. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less commonAcid or sour stomachanxietyback painbelchingblemishes on the skinbloatedbreast painburning feeling in the chest or stomachburning, dry, or itching eyeschange in color visionchanges in visioncold sweatscongestionconstipationcontinuing ringing or buzzing or other unexplained noise in the earscough producing mucusdecreased interest in sexual intercoursedifficulty seeing at nightdifficulty with movingdischarge, excessive tearingdouble visiondrooping upper eyelidsdull ache or feeling of pressure or heaviness in the legsearacheexcess air or gas in the stomach or intestinesfeeling of constant movement of self or surroundingsfeeling of warmthfeeling unusually coldfrequent urge to defecatefrozen shoulderfull feelinghearing lossheartburnhyperventilationinability to have or keep an erectionincreased appetiteincreased sensitivity of the eyes to sunlightincreased sputumindigestionirritabilityitching skin near damaged veinslack or loss of strengthloss in sexual ability, desire, drive, or performancemuscle or bone painmuscle stiffness or weaknessnightmaresnoisy breathingpain or tenderness around the eyes and cheekbonespassing gaspimplespoor concentrationrashredness of the face, neck, arms, and occasionally, upper chestredness, pain, swelling of the eye, eyelid, or inner lining of the eyelidredness, swelling, or soreness of the tonguerestlessnessseeing doublesensation of spinningsleepiness or unusual drowsinesssmall clicking, bubbling, or rattling sounds in the lung when listening with a stethoscopesmall lumps under the skinsore mouth or tonguestiff neckstomach bloating, burning, cramping, or painstomach discomfort or upsetstraining while passing stoolstuffy nosesudden sweatingswollen feet and anklestender, swollen glands in the necktenderness in the stomach areaterrifying dreams causing sleep disturbancestooth disordertrouble swallowinguncontrolled twisting movements of the neckvoice changesweight losswhite patches in the mouth, tongue, or throatOther side effects not listed may also occur in some patients. You need to take it every day in order for it to work. HHS Vulnerability Disclosure, Help Even if the medication is working, you may experience some unwanted side effects. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. You may report side effects to the FDA at 1-800-FDA-1088. Other side effects not listed may also occur in some patients. Disclaimer. Herbal supplements and heart medicines may not mix, Your blood pressure, if you also take a drug to treat high blood pressure, Beta blockers, such as atenolol (Tenormin), nadolol (Corgard) or propranolol (Inderal LA, Innopran XL), Calcium channel blockers, such as diltiazem, nifedipine (Procardia) and verapamil (Calan SR, Verelan), Nitrates, such as nitroglycerin (Nitrostat, Nitro-Dur, others) and isosorbide (Isordil, Bidil), Statins, such as atorvastatin (Lipitor), lovastatin (Altoprev) and rosuvastatin (Crestor), Anti-rejection medicine, also called immunosuppressant medicine, such as cyclosporine (Gengraf, Neoral, Sandimmune). Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks (chest pain). All rights reserved. Patient does not provide medical advice, diagnosis or treatment. Don't drink alcohol while taking isosorbide mononitrate (Monoket). Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Hawthorn. I would rather take the chance of a heart attack than have no quality of life. Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Isosorbide mononitrate (Monoket) is a nitrate vasodilator. View more. These side effects may go away during treatment as your body adjusts to the medicine. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Be sure to talk to your health care provider before you take any herbal supplements if you take prescription medicines. 8.0 out of 10 from a total of Daily headaches are a common side effect. Licorice. You may report side effects to Health Canada at 1-866-234-2345. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Of the total drug interactions, Do not drink alcohol while taking View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. For details see our conditions. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. Avoid combinations; the risk of the interaction outweighs the benefit. Some of the common derivatives include isosorbide dinitrate and isosorbide mononitrate, which are . All Rights Reserved. Isosorbide mononitrate systemic 60 mg (A ID). Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Never take extra doses or stop taking it suddenly unless your provider tells you to do so. 7.6 out of 10 from a total of St. Joseph 81 mg Aspirin Enteric Safety-Coated. 2023 Lybrate, Inc. All rights reserved. Clin Res Cardiol. https://naturalmedicines.therapeuticresearch.com. Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. Do not take two doses together to make up for a missed dose. Upgrade to Patient Pro Medical Professional? What You Need to Know, Angina (a specific type of chest pain) caused by heart disease. All rights reserved. This information is aggregated and used to produce personalized reports that patients can reference. View more, Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure. 8600 Rockville Pike Keep all medications away from children and pets. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. There are a number of medications that your doctor can prescribe in place of isosorbide mononitrate (Monoket). Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. It is also important information to carry with you in case of emergencies. Theyre fast, easy-to-use and free! Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat. Elsevier; 2021. https://www.clinicalkey.com. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. 2010; doi:10.1016/j.jacc.2009.07.074. Take your next dose at the regular time. Generic alternatives may be available. Unless there is a specific reason you need the brand, the generic medication will be a better value. Isosorbide tablets are also used with other medications to treat heart failure. sharing sensitive information, make sure youre on a federal There are 7 disease interactions with isosorbide mononitrate which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Last Revised - 09/15/2019. The drug donates nitric oxide to the body, which is similar to all other Isosorbide mononitrates. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. https://www.uptodate.com/contents/search. Bethesda, MD 20894, Web Policies Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Isosorbide Mononitrate side effects by likelihood and severity. The IR version can help treat and prevent angina. Mayo Clinic does not endorse companies or products. Enter other medications to view a detailed report. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. It is best not to drink alcohol while you are on isosorbide mononitrate. Isosorbide mononitrate (Monoket) can cause some serious health issues. As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. Accessed Sept. 7, 2022. Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood.