IRGs

Figure 1. Transmission electron microscope image of hybrid porous silica nanoparticles, synthesized via high-temperature aerosol methods. A,B) phase-segregated SiO2/Fe2O3 particles; superparamagnetic nanocomposite particles; C) nanoporous silica particles.

SEED Leaders: Sheryl Ehrman, Douglas English, Lyle Isaacs, Michael Zachariah

We are using ultra-sensitive fluorescence-based measurements to evaluate the effects of surface chemistry on the loading and release of model drugs in microporous metal-oxide nanoparticles. Specifically, we are evaluating alumina- and silica-based nanoparticles as potential platforms for the targeted delivery of drugs. These nanoparticles have extremely high internal surface areas and our MRSEC seed efforts focus on fundamental questions of the wettability and diffusion rates in nanoparticle interiors as a function of internal surface chemistry and morphology. These particles are produced by high-temperature aerosol methods and can be prepared as hybrid materials with magnetic oxides such as Fe₂O₃ to enhance their functionality (see Figure 1). To investigate the drug-delivery potential of microporous particles, we are currently conducting studies using the fluorescent model drug doxorubicin. Our novel microscope-based detection methods allow us to evaluate and track the transport of doxorubicin in microporous particles. The particles are synthesized by the Zachariah and Ehrman groups while measurements and surface modifications are made by the English laboratory and the Isaacs’ group.